Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing in the urine.
Antihistamines and codeine are the two contraindicated for use during the cure of decrease respiratory tract indications, which include bronchial asthma.
Promethazine hydrochloride takes place as being a white to faint yellow, nearly odorless, crystalline powder which slowly but surely oxidizes and turns blue on prolonged publicity to air.
This isn't a whole list of possible Negative effects. For those who discover other outcomes not mentioned previously mentioned, Call your physician or pharmacist.
Promethazine needs to be used with caution in people with bone marrow despair. Leukopenia and agranulocytosis have been reported, commonly when promethazine HCl has become Employed in association with other identified marrow-poisonous agents.
Lactation At the least one particular death was documented inside of a nursing infant who was exposed to substantial amounts of morphine in breast milk because the mother was an ultra-fast metabolizer of codeine.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Alternative Recommend people to correctly dispose of unused Promethazine HCl and Codeine Phosphate Oral Alternative. Suggest individuals to toss the drug within the household trash following these techniques. 1) Take away them from their authentic containers and blend them with the unwanted substance, like made use of espresso grounds or kitty litter (this can make the drug fewer captivating to young children and pets, and unrecognizable to folks who may well intentionally go in the trash looking for medicine).
Your mouth could get dry. Chewing sugarless gum or sucking tough candy and drinking loads of water could assistance. Make contact with your care team if the challenge would not disappear or is significant.
Examine the Medication Guide supplied by your pharmacist Before you begin taking codeine/promethazine and every time you Promethazine codeine syrup receive a refill. When you have any concerns, inquire your medical professional or pharmacist.
Promethazine is metabolized by the liver to a range of inactive metabolites which include sulfoxides of promethazine, N-demethylpromethazine and also other glucuronides.
The dosage is predicated on the age, health-related ailment, and response to remedy. Diligently evaluate the dose using a Exclusive measuring system/spoon. Never use a household spoon simply because you might not get the proper dose.
Ailments OF USE: The data In this particular databases is intended to dietary supplement, not substitute for, the abilities and judgment of healthcare pros. The information will not be meant to deal with all doable uses, Instructions, safeguards, drug interactions or adverse results, nor really should or not it's construed to point that usage of a particular drug is Harmless, ideal or powerful for you personally or anyone else.
Sedating medication could bring about confusion and more than-sedation within the aged; aged sufferers commonly ought to be started out on very low doses of promethazine with codeine syrup and observed intently.
To help avoid withdrawal, your physician might lower your dose slowly and gradually. Withdrawal is much more possible if you have utilized this medication for a very long time (various months) or in higher doses. Explain to your medical doctor or pharmacist immediately When you have withdrawal.